Paul O'Reilly

I am a Senior Lecturer in Statistical Genetics at the MRC SGDP Centre, Institute of Psychiatry, King's College London. I did my PhD at Imperial College London (2004-08) supervised by David Balding and co-supervised by Ewan Birney. After a post-doc with Marjo-Riitta Jarvelin and Lachlan Coin, working on numerous GWAS projects and methods development, particularly multivariate GWAS (MultiPhen) and inversion polymorphisms, I began a lectureship at Imperial in 2011, before moving to King's in 2013. At King's I've focused on polygenic risk score methodology (PRSice) and have had a nice time getting to know psychiatric genetics.

Contact: paul.oreilly@kcl.ac.uk
twitter.com/paul_f_oreilly


Methods & Software


Selected Publications

Plomin, R., Krapohl, E., O’Reilly, PF. 2016. Assortative Mating – A Missing Piece in the Jigsaw of Psychiatric Genetics. JAMA Psychiatry 73:323-4.

Euesden, J., Lewis, CM., O'Reilly, PF. 2015. PRSice: Polygenic Risk Score software. Bioinformatics 31:1466-8.

Asherson, P., O'Reilly, PF. 2015. Genetic Effects, Categorical Disorders and Quantitative Traits. J Am Acad Child Adolesc Psychiatry 54:702-3.

Seich al Basatena, NK., Hoggart, CJ., Coin, LJ., O'Reilly, PF. 2013. The effect of genomic inversions on the estimation of population genetic parameters from SNP data. Genetics. doi: 10.1534/genetics.112.145599

O'Reilly, PF. et al. 2012. MultiPhen: Joint model of multiple phenotypes can increase discovery in GWAS. PLoS ONE. 7:e34861.

Hoggart, CJ.*, O'Reilly, PF.* et al. 2012. Fine-scale Estimation of Location of Birth from Genome-wide SNP Data. Genetics. 190: 669-677.

O'Reilly, PF., Balding, DJ. 2011. Admixture provides new insights into recombination. Nature Genetics. 43, 819–820

Wain, LV.*, Verwoert, GC.*, O'Reilly, PF.*, et al. 2011. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.  Nature Genetics 43: 1005–1011

O'Reilly, PF., Coin, L., Hoggart, C. 2010. invertFREGENE: Software for simulating inversions in population genetics data. Bioinformatics. 26: 838-40

Pillas, D.*, Hoggart, CJ.*, Evans, D.*, O'Reilly, PF.*, et al. 2010. Genome-wide association study reveals multiple loci associated with primary tooth development. PLoS Genetics. 6(2): e1000856.

O'Reilly, PF., Birney, E., Balding, DJ. 2008. Confounding between recombination and selection, and the Ped/Pop method for detecting selection. Genome Research. 18: 1304-1313.


Talks

Bloomsbury Centre Seminar Series, London, Nov 2013. "Increasing statistical power in GWAS"

WCPG, Boston, Oct 2013. "MultiPhen: Joint model of multiple phenotypes increases discovery in GWAS"

ASHG, Montreal, Oct 2011. "MultiPhen: Joint model of multiple phenotypes increases discovery in GWAS"

EMGM, London, Apr 2011. "Joint modelling of multiple phenotypes in GWAS"

ASHG, Washington DC, Nov 2010. "The simulation, detection, and effect of inversions in the human genome"

MASAMB, London, Apr 2009. "invertHMM: Detecting inversions in the Human Genome from SNP data"

HGV, Toronto, Oct 2008. “invertHMM: Detecting inversions in the Human Genome from SNP data”

IGES, York, Sept 2007. “Confounding between recombination and selection, & the Ped/Pop method...” (abstract in Genetic Epidemiology, Aug 2007)

EMGM, Heidelberg, Apr 2007. “Confounding between recombination and selection, & the Ped/Pop method...” (abstract in Annals of Human Genetics, Jul 2007)


Teaching

I currently teach on, and am Module Leader for, the Statistical Genetics module on the MSc Genes Environment and Development and on the Summer School: Analysis of Genetic Association Studies at the MRC SGDP Centre, IoPPN, King's College London. Previously, at Imperial College London, I taught statistics & epidemiology on the Medicine Undergraduate course, and statistics and statistical genetics on the MSc Bioinformatics, MSc Modern Epidemiology and Masters in Public Health courses.

Other roles

I am organiser of the South of England Genetic Epidemiology Group (SEGEG),  Associate Editor for BMC Genomics, Deputy Programme Leader of the MSc Genes Environment and Development and a scientific director (along with Cathryn Lewis) of the Summer School: Analysis of Genetic Association Studies at the MRC SGDP Centre, IoPPN, King's College London.